Chronic myeloid leukemia (cml) is a genetic disorder associated with the philadelphia chromosome. the philadelphia chromosome is a mutation in chromosome 22. part of chromosome 22 is exchanged with part of chromosome 9, bringing together two genes on chromosome 22 and causing a malignancy. what type of mutation occurs in the philadelphia chromosome? a. duplication b. insertion c. inversion d. substitution e. translocation

The correct answer option is E. translocation.

Explanation:

Philadelphia chromosome are CML and Philadelphia chromosome-positive ALL are the leukemias that are caused by a mutation.

This type of mutation which occurs in the  occurs in the Philadelphia chromosome is called translocation.

Philadelphia chromosome contains a fusion gene which consists of the ABL gene and the BCR gene, producing the BCR-ABL oncogene which has an enzyme with an abnormal tyrosine kinase activity.

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