The term _ describes a change in the structure of cells and in their orientation to each other

Anaplasia

Explanation:

The term Anaplasia came from a greek word which refers to a conditon in which  cells  are not differentiated in a proper way for a proper role,they donot have distinct morphological characteristics and they donot posses orientation with respect to each other.

In simple words we can say that these cells lose the ability to form specific tissues.Normally cells differentiate to form specific tissues when they mature, but during Anaplasia these cells de-differentiate and grow in larger size than a normal cell.These cells are not actively communicating with the neighboring cells and form malignant tumors in the body.

This can become an extremely dangerous condition, because the newly colonized tumors can start to grow quickly and create serious cancers in the body leading to death.

Hope it help!