If huntington’s disease is due to a dominant trait, shouldn’t three-fourths of the population have huntington’s while one-fourth has the normal

Huntington's disease is due to an expansion of repeated CAG triplets (at 36 or more repeats) on the short arm of chromosome 4 in the HTT gene of huntingtin.

The prevalence in the Caucasian population is estimated at 1 / 20,000 to 1 / 10,000. This is higher compared to a disease with autosomal recessive inheritance.

It should be known that this disease affects only certain families where a heterozygote has a chance to transmit it (1/2), this is due to a mutation in their gene.

Despite its dominant character, it remains a rare disease due to its recent appearance (discovered in the 19th century) and also the rarity of the mutation.

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