Tubulovillous adenoma with high grade dysplasia

Explanation:

Adenomatous genes are most often found among neoplastic genes and are the target of 2/3 of all colon members. The factors of risks associated with its onset include advanced age, sedentary lifestyle, male gender and increased BMI / abdominal fat. Dysplasia gives it the potential for malignancy, constituting the precursors of most, however, only 5% of adenomas evolve to carcinoma by a process that runs from 7 to 10 years, with the greater risk of progression for advanced adenomas. Adenomatous polyps can be classified into 3 subtypes based on epithelial architecture:

Tubular adenoma: represent about 80% of all adenomas and are characterized by the presence of tubular glands in at least less than 75% of the architecture.

Villous adenoma: account for 5 to 15% of all adenomas and have glands with villous projections in at least 75% of its architecture.

Tubulovillous adenoma: correspond to 5 to 15% of adenomas and has mixed histology with less than 75% of both types of architectures.

High-grade dysplasia is characterized by a complex architecture where there are grouping and glandular irregularity as well as a cribriform pattern and cytological atypia, with loss of nuclear polarity, enlarged nuclei with nucleoli, atypical mitoses, and prominent apoptosis. The high-grade dysplasia has a higher risk of developing for carcinoma

the answer is d p: cell, q: organ, r: organ system, s: tissue