why cant water move directly through the lipid bilayer?

Water can diffuse through the lipid bilayer even though it's polar because it's a very small molecule. Water can also pass through the cell membrane by osmosis, because of the high osmotic pressure difference between the inside and the outside the cell.

this protocol provides a detailed procedure for agarose-based ip to purify and enrich the protein of interest.

allowed for the prediction of the properties of missing elements.