Two circular dna molecules are topoisomers of each other; they contain the same amount of dna. let’s call them dna-1 and dna-2. under the electron microscope, dna-1 appears more compact compared to dna-2. the level of gene transcription is much lower for dna-2. which of the following three possibilities would best explain these observations? a) dna-1 has 4 positive supercoils and dna-2 has 2 negative supercoils. b) dna-1 has 2 positive supercoils and dna-2 has 4 negative supercoils. c) dna-1 has 4 negative supercoils and dna-2 has 2 positive supercoils.