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Biology, 01.11.2019 07:31 zoedaejohnson

Imagine that two protein kinases, pk1 and pk2, act sequentially in an intracellular signaling pathway. when either kinase is completely inactivated, the cells don’t respond to the signal. doubly mutant cells that contain inactivated pk2 and permanently active pk1 respond in the absence of a signal. in the normal signaling pathway, does pk1 activate pk2 or does pk2 activate pk1? what outcome would you have predicted for a doubly mutant cell line with an activating mutation in pk2 and an inactivating mutation in pk1?

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