How are sister chromatids and homologous chromosomes different from each other? see concept 13.3 (page) view available hint(s) how are sister chromatids and homologous chromosomes different from each other? see concept 13.3 (page) they are not different. homologous chromosomes and sister chromatids are both identical copies of each other. sister chromatids are only formed during mitosis. homologous chromosomes are formed during meiosis. homologous chromosomes are identical copies of each other. one sister chromatid comes from the father, and one comes from the mother. homologous chromosomes contain the same gene loci but may have different alleles of a particular gene. sister chromatids are identical copies of each other produced during dna replication. homologous chromosomes are closely associated with each other in both mitosis and meiosis. sister chromatids are only associated with each other during mitosis.