According to his first book, how was john smith set free?
&
according to his second book, how was john smith set free?

G protein-coupled receptors (GPCRs), or seven transmembrane receptors (7TMs), are the largest family of cell-surface molecules involved in signal transmission (Rebert 2007). GPCRs have drawn much attention for treating hypertension, neurological, pain and other disorders, as more than 40% of the clinically marketed drugs are targeting GPCRs.

https://www.creative-biogene.com/Services/Drug-Discovery-Services/GPCR-Screening-Assays.html

Explanation:

the answer would be knowledge about cars!

a physical change is being made.