Phosphorylation cascades are similar to a row of dominoes falling down, instead of one domino knocking down the next, a phosphate being added activates the message. in this way, a series of different are each one after another. inactive protein kinase 1 gets a added and now it is protein kinase 1. active protein kinase 1 transfers a and now inactive protein kinase 2 is now this continues until the desired is activated to cause a cellular response.