Alpha helix and beta sheet secondary structure is located mainly in the interior of folded proteins whereas irregular loops occur on the

of folded proteins

Explanation:

In Secondary structures; the irregular loops seems to be positioned on the outside of folded proteins while the Alpha and beta sheets is categorically positioned at the centre or interior of the protein.

The loops are positioned on the outside of folded proteins in order for the peptide bonds to be open to form H bonds with water.

from the original order (top to bottom) the new order will go

1 (founder)

4 (hawk)

2 (mutate)

3 (next generation)