The three-dimensional structure of macromolecules is formed and maintained primarily through noncovalent interactions. which one of the following, if any, is not considered a noncovalent interaction.

Carbon-Carbon bond is not considered as a noncovalent interaction because electrons are shared between the two carbons forming a strong covalent bond.

Explanation:

Non covalent interactions does not involve sharing of  electrons rather it involves dispersed variation of electromagnetic interactions between the molecules.

Examples include;

Hydrogen bond- in order to be formed the donor Atom has to be electronegative

Ionic interactions- These are attractions between two oppositely charged ions

Van der waals- It is formed due to small , transient asymmetric electron distribution around atoms