Write a one sentence explanation for the following statement:

the presence in liver of glucose-6-phosphatase is essential to the function of the liver in synthesizing glucose for use by other tissues.
a. glucose-6-phosphate must be hydrolyzed in order for glucose to exit the liver cell and be exported to other tissues.
b. glucose-6-phosphate must be fully ucleaved in order for glucose to exit the liver cell and be exported to other tissues.
c. glucose-6-phosphate must lower the energy barier of desorption in order for glucose to exit the liver cell and be exported to other tissues.
d. glucose-6-phosphate must be activated in order for glucose to exit the liver cell and be exported to other tissues.

a. Glucose-6-phosphate must be hydrolyzed in order for glucose to exit the liver cell and be exported to other tissues

Explanation:

Liver cells contain a membrane bound enzyme called glucose-6-phosphatase for glycogenolysis by glucagon especially during starvation when free glucose is required. As glucagon enters the liver cells it activates the enzyme glucose-6-phosphatase which then acts on glucose-6-phosphate and hydrolyzes it. As glucose-6-phosphate is hydrolyzed, it results in the formation of a phosphate group and a free glucose. The free glucose thus formed is transported from the liver cell to other tissues by specific glucose transport membrane protiens.

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