Researchers can manipulate the genes of a mouse so that a single gene in a single tissue either produces an inactive protein (a knockout mouse) or produces a protein that is always (constitutively) active. What effects on metabolism would you predict for mice with the following genetic changes?

Knockout of the FBPase-2 domain of PFK-2/FBPase-2 in the liver:

1) Effect on glucose metabolism:
2) Effect on glucose levels:

Constitutively active PFK-2 in the liver:

1) Effect on glucose metabolism:
2) Effect on glucose levels:

a. 1

b. 2

Fructose-2,6-bisphosphate (F2,6P) activates the key glycolysis enzyme, phosphofructokinase (PFK) and inhibits fructose bisphosphate phosphatase in gluconeogenesis. F2,6P is synthesized by phosphofructokinase-2 (PFK-2) and broken down by fructose-bisphosphatase-2 (FBPase-2). Both PFK-2 and FBPase-2 are found in the liver. PFK-2 is activated by insulin in response to high glucose levels. FBPase-2 activity in increased by glucagon when glucose needs to be metabolized.

Explanation:

the framers of the constitution insisted that federal judges be nominated instead of elected due to their desire to have judges above the shifting whims of the masses.

the hope, whether achieved or not, was that federal judges would only be beholden to the law and that by not having judges be elected, they would be protected if that law dictated an outcome that ran counter to popular opinion.

mientras se trata la anorexia o la bulimia, es importante buscar ayuda antes que nada. un profesional de la salud mental será el más útil para aquellos que sufren anorexia o bulimia. este es un buen lugar para comenzar, sin embargo, ver a otros profesionales como dietistas registrados, especialistas médicos y dentistas podría ayudar a alguien a recuperarse de un trastorno alimentario. después de la ayuda profesional, o si la ayuda profesional no es una opción, alguien que se recupere de la anorexia o la bulimia debe rodearse de compañeros de apoyo, padres u otros miembros de la familia que también estén comprometidos con el proceso de recuperación.

hope this you! : )

(i popped my answer into google translate so it may be a bit wonky)