Arrange the following events in endochondral ossification in proper sequence:

(1)Cartilage matrix is calcified and chondrocytes die.
(2)Chondrocytes hypertrophy.
(3)Cartilage model is formed.
(4)Osteoblasts deposit bone on the surface of the calcified cartilage called the primary ossification center.
(5)Blood vessels from the periosteum invade calcified cartilage bringing in osteoblasts and osteoclasts.

a. 3, 2, 1, 5, 4
b. 3, 2, 5, 4, 1
c. 3, 2, 5, 1, 4
d. 3, 5, 2, 4, 1
e. 1, 3, 4, 5, 2

The correct answer is: c) 3, 2, 5, 1, 4.

Explanation:

Endochondral ossification is the process in which bone tissue is formed from a cartilage model, unlike intramembranous ossification in which bone cells originate from mesenchymal stem cells. Endochondral ossification is key to: 1) the rudimentary formation of long bones, 2) the growth in lenght of long bones, and 3) the reparation if bone tissue when the bone is fractured.

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