You purified fragments of the nuclear envelope from human fibroblasts by biochemical fractionation. You first decide to use electron microscopy to test for the presence of the nuclear lamina on these envelope fragments.
Which of the following structures would suggest the presence of the nuclear lamina?

A. "little bumps", presumably membrane proteins, at the surface of the inner membrane
B. two phospholipids bilayers ~300 and ~700 nm fibers an organized meshwork of ~ 10 nm fibers
C. large pores that span through both nuclear membranes

A, B and C represents the presence of a nuclear lamina

Explanation:

The structure of a nucleus can be represented by the presence of large pores that allow transport between the nucleus and cytosol. Also the nucleus is mechanically supported by network of intermediate filaments called the nuclear lamina, which forms a thin sheetlike meshwork just beneath the nuclear inner membrane.

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