What are the negative effects of this destruction on the global environment as well as on the local environment?

The negative effects of the destruction on the global environment as well as on the local environment are the following :

1) If forests are destroyed for making commercial area, the habitat of animals are also destroyed.

2) Forest helps in the cleaning of environment by consuming carbondioxide and releasing oxygen. If destruction of forest occurs, the environment remains polluted.

an active site is a region that is present on an enzyme where the reactants or the substrate molecules we can say bind and experience a chemical reaction. the substrate is basically a reactant whose concentration is changing and that is converting into a product after binding at the active site of an enzyme