Assume a biallelic locus in a diploid population has the genotype frequencies: A1A1 = 0.59; A1A2 = 0.16; and A2A2 = 0.25. What is the observed allele frequency (p) of the A1 allele?

Explanation:

Given

A1A1= 0.59;

A1A2= 0.16;

A2A2 = 0.25

p =Frequency of (A1)

q = freq (A2)

p = freq(A1A1) + (1/2) freq(A1A2)

= 0.59 + (1/2)(0.16) = 0.67.

0.67 is the observed allele frequency (p) of the A1 allele.

q= freq(A2A2) + (1/2) freq(A1A2)

or directly

q = 1-p = 0.33

genetic variation can be caused by mutation (which can create entirely new alleles in a population), random mating, random fertilization, and recombination between homologous chromosomes during meiosis (which reshuffles alleles within an organism's offspring).

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