The enzyme phosphofructokinase (PFK) catalyzes a key step in glycolysis. About 10% of Springer spaniels suffer from canine PFK deficiency. Given its critical role in glycolysis, which of the following conditions would be a likely consequence for dogs afflicted with this disorder? A) They would die as embryos. B) They would have elevated blood-glucose levels, which may result in a high incidence of diabetes. C) They would be lethargic and readily tire from exercise. D) They would carry out elevated levels of oxidative phosphorylation.

The correct option is (C)

Explanation:

The third step of Glycolysis is controlled by an enzyme PhosphofructokinaseIt means, the phosphofructokinase helps in the conversion of fructose-6-phosphate into fructose-1,6-biphosphate(F1,6BP)The phosphate group from ATP to F6P is transfer by PhosphofructokinaseThis step in glycolysis is the rate limiting step because it is the slowest reaction in glycolysisPFK is inhibited by low pH levels, high levels of ATP, high levels of citrateThe increase in the levels of Fructose 2,6 bisphosphate and adenosine monophosphate activate PFK and thus increases the rate of Glycolysis