Transformation is a useful technique for making genetically modified bacteria in the laboratory. There have been efforts to transform Archaea, but it has been more difficult than transforming Bacteria. One reason that it has been difficult is that Archaea lack a peptidoglycan cell wall. Why does that affect the ability of researchers to develop techniques to transform them

Transforming Bacteria

Explanation:

Archaea and bacteria are different in the qualities of the cell wall and in the lipid composition of their cell membranesBacterial cell dividers contain peptidoglycanArchaean cell wall don't have peptidoglycan, yet they may have , polysaccharides, glycoproteins, or protein-based cell dividers Bacterial cell walls are made of peptidoglycan (likewise called murein), which is produced using polysaccharide chains cross-connected by abnormal peptides containing D-amino acids