Sickling occurs in deoxyhemoglobin S but not in oxyhemoglobin S. Oxyhemoglobin has a small, hydrophobic pocket in a β chain region located in the interior of the protein. In deoxyhemoglobin, however, this pocket is located on the surface of the protein. In deoxyhemoglobin S, Val 6 6 interacts with this surface pocket, leading to aggregation of HbS. Choose two amino acids that would be reasonable candidates for the pocket–Val 6 6 interaction.

hi my name is ashlynn and im 15

these macromolecules could either be amino acids, proteins or nucleic acids. they are responsible for the chemical changes and reactions that affects largely the cell and its composition. take for instance the cytoplasm of the cell where these organelles are settled. these simple organelles are composed of macromolecules which ignites and catalyses different functions that enables cells, in macro-perspective in motion and metabolism. in intestines for example, metabolism happens and breaking down parts of a food to simpler compounds that are used and these nutrients delivered throughout the body and again broken down by into smaller components.