Exposure of zebrafish nuclei to meiotic cytosol resulted in phosphorylation of NEP55 and L68 proteins by cyclin-dependent kinase 2. NEP55 is a protein of the inner nuclear membrane, and L68 is a protein of the nuclear lamina. What is the most likely role of phosphorylation of these proteins in the process of mitosis?

THEY ARE INVOLVED IN THE DISASSEMBLY OF THE NUCLEAR ENVELOPE

Explanation: The disassembly of the nuclear envelope is triggered by the cyclin‐dependent kinase at the onset of mitosis. At this point, Integral nuclear membrane proteins diffuse/move into the endoplasmic reticulum (ER) after nuclear envelope breakdown. The nuclear envelope reassembles around compact chromosome mass at late anaphase/telophase and the chromosomes condenses and become visible.

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