Ingested water-soluble drugs follow the same absorption pathway as sugars and amino acids. Choose the most direct pathway for a water-soluble antidepressant, from absorption at the GI tract mucosa until it reaches the brain:

a. Lymphatic system > hepatic portal vein > portal venule rightarrow sinusoid > central vein > hepatic vein > heart & lungs > arteries > brain
b. Lymphatic system > veins > heart & lungs > arteries > brain
c. Hepatic artery > portal arteriole > sinusoid > central vein > hepatic vein > heart & lungs > arteries > brain
d. Veins > heart & lungs > hepatic artery > portal arteriole > sinusoid central vein > hepatic vein > heart & lungs > brain
e. Hepatic portal vein > portal venule > sinusoid > central vein > hepatic vein > heart & lungs > arteries > brain