Select the true statements regarding antibody (specifically, immunoglobulin G) structure.

a. Both the Fab and Fc fragments have variable domains.
b. The antigen‑binding site is formed as a combination of variable domains from one heavy and one light chain.
c. The heavy and light chains are linked by noncovalent and disulfide bonds.
d. The antigen‑binding site is located in the Fab fragment.
e. Only the Fc fragment has constant domains.

Option b, c and d are correct

Explanation:

The heavy and light chains of the antibody or IgG are linked together by non co-valent and disulfide bonds.

The antigen-binding place of the complex is formed by the combination of variable domains which is formed by the combination of one light chain and one heavy chain. Antigen binding site, also known as paratope.

The antigen binding site in an antibody is located only on Fab arm of the IgG which functions by binding to the antigen.