This is one possible cross (above) for the X-linked condition known as hemophilia. Which pair of parents is most likely to have hemophiliac daughter

The options:

A. A hemophiliac mother and an unaffected father

B. A carrier mother and an unaffected father

C. A carrier mother and a hemophiliac father

D. An unaffected, non-carrier mother and a hemophiliac father

The CORRECT ANSWER IS C.

C. A carrier mother and a hemophiliac father

Explanation:

Hemophilia is known to be a recessive disorder, a woman would need to have two disease alleles (positioned on both X chromosome) for the disease to be expressed. Therefore, she would need to possess the disease allele from both parents (mother and father).

Hemophilia is an X-linked disorder, and it is hemizygous for male in terms of the hemophilia-related gene (with only a singular allele and express the phenotype linked with the allele). For the hemophilia allele to be inherited in an offspring, the male has to be hemophiliac.

Pairs of parents without a hemophiliac male would not have a hemophiliac daughter, excluding rare conditions (spontaneous mutations occuring in the germline or at growth and maturation of the embryo).

A homozygous woman for this condition (is hemophiliac) or heterozygous woman for the allele in consideration (is an unaffected carriers) could transfer a hemophilia allele to her offspring.

Pairs of parents that without a hemophiliac female or hemophiliac carrier would not yield a hemophiliac daughter (with the exclusion of rare spontaneous mutation situations).

Of the pairs above, a carrier mother and a hemophiliac father would most probably produce a hemophiliac daughter.

Mother is a carrier and Father is a hemophilia.

Refer below for the explanation.

Explanation:

Both X cromosome linked in the daughter results in hemophiliac daughter.

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