Phenylketonuria (PKU) is a condition of newborns caused by an autosomal recessive allele. The incidence of PKU is one in 160,000 births in China, one in 2600 births in Turkey

Full Question

Phenylketonuria (PKU) is a condition of newborns caused by an autosomal recessive allele. The incidence of PKU is one in 160,000 births in China, one in 2600 births in Turkey, and one in 119,000 births in Japan. The frequency of carriers in Turkey is

The frequency of carriers in Turkey is 0.038%

Explanation:

Given

Incidence of PKU in China = 1 in 160,000 births

Incidence of PKU in Turkey = 1 in 2,600 births

Incidence of PKU in Japan = 1 in 119,000 births

Total = Incidence of PKU in China + Incidence of PKU in Turkey + Incidence of PKU in Japan

Total = 160,000 + 2,600 + 119,000

Total = 281,600 in the three countries

The frequency of carriers in Turkey is calculated as follows;

If there are 2600 births, there will be an incidence of 1 PKU (Phenylketonuria);

Frequency = 1/2600

Frequency = 0.0003846154

Frequency = 0.03846154%

Frequency = 0.038% --- Approximated

Hence, the frequency of carriers in Turkey is 0.038%

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