ATP synthase is a large molecular machine that converts the energy in an electrochemical gradient into the bond energy stored in ATP.

Which of the following events are required for the synthesis of ATP?

Choose one or more:

A. movement of protons down their gradient through ATP synthase

B. conformational changes of the F1 ATPase

C. binding of ATP to an empty F1 ATPase subunit

D. rotation of the rotor in the membrane

Ms. w, a 21-year-old woman, came into a clinic after suffering a deep laceration on her foot while walking barefoot around her yard. the wound was cleaned, sutured, and bandaged, and she was released to return home after receiving tetanus antitoxoid. within 72 hours, the wound area was red and swollen, the suture line was dark in color, and it was accompanied by severe throbbing pain. ms. w had a high fever, her heart felt like it was racing, and she was finding it hard to concentraten even on simple tasks. she returned to the clinic and was immediately taken to the hospital. following lab tests, a diagnosis of acute necrotizing fasciitis was made. discussion questions 1. explain why ms. w. received a tetanus antitoxoid before leaving the hospital. (see chapters 3 and 4, infection and passive immunity.) 2. explain how acute necrotizing fasciitis developed in this case and the pathophysiology involved. (see acute necrotizing fasciitis.) 3. what is the potential outcome for ms. w if antibiotic drugs do not reduce the infection quickly?