G What is the advantage of having Complexes I, III, and IV associated with one another in the form of a respirasome? The respirasome allows NADH NADH and FADH 2 FADH2 to interact directly with the inner mitochondrial membrane. A respirasome composed of Complexes I, III, and IV allows the efficient transfer of electrons from FADH 2 FADH2 to oxygen. It facilitates the energetically unfavorable electron transfer reactions carried out by Complexes I, III, and IV. It enables the rapid transfer of electrons, thereby increasing the efficiency of proton pumping.