When does homologous recombination most likely occur in order to flawlessly repair double-stranded DNA breaks? Group of answer choices

A. before DNA is replicated, to avoid propagating the error

B. when the damage is overlooked by the fast-acting mismatch repair system

C. after the cell’s DNA has been replicated

D. after the broken ends have been "cleaned" by a nuclease

E. whenever a double-strand break is detected