Which of the following are true in regards to the use of double stranded break (DSB) mechanisms for genome editing? Select all that apply. Group of answer choices One of the main advantages of these systems is that it is possible to generate mutations in a sequence-independent manner. The addition of foreign DNA can lead to specific gene modifications. These mechanisms are specific for prokaryotes. Repair of breaks by NHEJ can lead to gene inactivation.

One of the main advantages of these systems is that it is possible to generate mutations in a sequence-independent manner.

The addition of foreign DNA can lead to specific gene modifications.

Explanation:

Double strand break mechanism for genome editing deals with the cellular machinery that repairs in a timely manner the break through the error prone non-homologous end-joining (NHEJ) error prone pathway that often results in insertions and deletions.

One of the main advantages of these systems is that it is possible to generate mutations in a sequence-independent manner.

The addition of foreign DNA can lead to specific gene modifications.