The map shows the allele frequency of sickled hemoglobin and malaria endemicity in Africa. Which statement best explains the relationship between allele frequency and malaria endemicity in Africa?
When an area is malaria free, the allele frequency is between 0 and 2.02.
When an area is holoendemic, the allele frequency is between 0.52 and 4.04.
When an area is malaria free, the allele frequency is between 12.64 and 18.18.
When an area is holoendemic, the allele frequency is between 0 and 0.51.