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Biology, 18.06.2020 13:57 natalie2sheffield

Genetic analysis identified a 10 kb segment of human DNA that correlated to a protein-encoded disease phenotype. How would you use at least three methods to identify the 1 nucleotide in this 10 kb that is responsible for the disease phenotype? Note that there are on average ~8 nucleotide polymorphisms in 10 kb. You do have family members, model organisms, and a biochemical assay available to you.

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