Biochemical changes in the body, that affect the rate of metabolism and elimination of a substance from the body and produce increased amounts to achieve the desired effects, may lead to development of

Tolerance

Explanation:

Tolerance is the capacity of an organism to survive changes in certain environmental and biochemical conditions. It has to with changes an organism is able to withstand when is subjected to certain factors which can biotic or abiotic.

For example, in the consumption of alcohol, tolerance can occur when there is a fast elimination of alcohol from the body system. This is usually as a result of the activation of a group of enzymes that is responsible for the metabolism of alcohol in excessive alcohol drinkers. The activation of this enzymes increases the catabolism of alcohol and hence reduces the active time within the body, hence reducing the time by which alcohol intoxicates.

when you breathe in, or inhale, your diaphragm contracts (tightens) and moves downward. this increases the space in your chest cavity, into which your lungs expand. the intercostal muscles between your ribs also enlarge the chest cavity. they contract to pull your rib cage both upward and outward when you inhale.