Rank from the first to the last steps to describe the correct order of events of erythrocyte death.

1. erythrocyte becomes trapped in the sinusoids of spleen.

2. Spleen macrophages digest the erythrocytes.

3. Hemoglobin is broken down into amino acids, iron and bilirubin.

4. Iron ions and amino acids are recycled to make new hemoglobin in red bone marrow. Bilirubin is sent to liver for excretion.

Explanation

Aging erythrocytes are trapped in the sinusoids of the spleen, where they are digested by macrophages. Within the macrophage, hemoglobin is broken down into amino acids, iron ions, and bilirubin.

Iron ions or heme ion and amino acids then move through the blood to the bone marrow, where they are recycled and used to create new hemoglobin. Bilirubin travels with the help of the blood to the liver, where it is modified and then excreted.

thus, the correct order is :

1. erythrocyte becomesrapped in the sinusoids of spleen.

2. Spleen macrophages digest the erythrocytes.

3. Hemoglobin is broken down into amino acids, iron and bilirubin.

4. Iron ions and amino acids are recycled to make new hemoglobin in red bone marrow. Bilirubin is sent to liver for excretion.

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