When an enzymatic reaction is in progress, do you expect to see an increase, decrease or no change in each of following: (i) substrate (ii) product (iii) enzyme

During Enzymatic reaction, enzymes binds to a substrate to form a which then forms the product.

Change in shape of substrate, product and enzymes depends on the temperature outside the optimal range which affect bonding between enzyme and substrate. Enzymes definitely changes their size when bind to substrat and the process is called induced fit which increases the rate of reaction.

the supermassive black hole is in the middle of the galaxy.

the framers of the constitution insisted that federal judges be nominated instead of elected due to their desire to have judges above the shifting whims of the masses.

the hope, whether achieved or not, was that federal judges would only be beholden to the law and that by not having judges be elected, they would be protected if that law dictated an outcome that ran counter to popular opinion.