7. Health Medicine, alcohol, and many drugs are detoxified in
liver cells. Why do you think
the liver cells of some people
who abuse alcohol and drugs
have an increased amount of
smooth ER?

This adaptation is due to increased volume (hypertrophy) of the smooth ER of hepatocytes, which metabolizes the drug. ... With prolonged use, the barbiturates (and many other agents) stimulate the synthesis of more enzymes, as well as more smooth ER.J