A comatose infant is brought to the ER. In the course of the examination, plasma ammonia was found to be elevated 20-fold over normal values. Urine orotic acid and uracil, that require carbamoyl phosphate for their formation, were both greater than normal. A defect of which of the following enzymes is the most likely diagnosis?A. ArginaseB. Argininosuccinate lyaseC. Carbamoyl phosphate synthetase 1 (ammonia substrate)D. Carbamoyl phosphate synthetase 2 (glutamine substrate)E. Ornithine transcarbamoylase

Explain the significance of thesaurus geographicus

The kidney filters potentially toxic substances in the blood, and thus “clears” the blood of those substances. this clearance function is dependent upon and proportional to the diffusion gradient of the substance across filtering capillaries, i.e. if the concentration of the substance is doubled, twice as much will be cleared from each ml of blood that is filtered. suppose that the body produces a constant amount of a substance x per unit of time. the kidneys eliminate substance x at a rate directly proportional to the concentration of the substance and the volume of blood cleared each minute (c): elimination = c × [x], where [x] is the steady-state concentration of substance x. imagine an individual with an initial concentration of x equal to [x]0 who develops kidney disease. her baseline clearance c0 drops to one half of the original (½c0). what is the new steady state concentration of x? (for simplicity, assume that substance x is 100% filtered by the kidney).

Which of the following describes the difference in stimuli required to detect a difference between the stimuli? a. just noticeableb. signal detectionc. subliminald. top down