The enzymes that catalyze cellular reactions are macromolecules made of organic compounds
composed of carbon, hydrogen, oxygen, and
nitrogen. These types of macromolecules are
known as -

the last one: artificial selection/genetic engineering

plant breeding is modifying the genetic composition of the plant - but this isn't cloning (which is specifically introducing a gene into a genome). but you are artificially selecting for the phenotype that you want.

the second one is literally genetic engineering - the gene would have been cloned first and then inserted or genetically engineered into the new plant cell (the cotton).

loss of sensation to pressure and touch

the dorsal column–medial lemniscus pathway (dcml) (also known as the posterior column-medial lemniscus pathway (pcml)) is a sensory pathway of the central nervous system that conveys sensations of fine touch, vibration, two-point discrimination, and proprioception (position) from the skin and joints.