The instructions for making protein comes originally from

The instructions for making protein comes originally from GENES.

Explanation:

Genes, present in nuclei of cells, contain information in DNA needed to produce proteins(functional molecules).

This process consists of two major steps: TRANSCRIPTION AND TRANSLATION. Together, transcription and translation are known as gene expression.

In transcription, the messenger RNA(mRNA), carries the information, or message, from the DNA out of the nucleus into the cytoplasm.

Translation occurs in the cytoplasm and here the mRNA interacts with a ribosome which "reads" the sequence of mRNA bases.

A type of RNA called transfer RNA (tRNA) then assembles the protein, one amino acid at a time.