2. The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate to acetyl-CoA, a substrate for the Krebs (citric acid) cycle The rate of pyruvate conversion is greatly reduced in individuals with PDC deficiency, a rare
disorder. (1-9)
(a) identify the cellular location where PDC is most active.
(b) make a claim about how PDC deficiency affects the amount of NADH produced by glycolysis AND the amount of NADH produced by the Krebs (citric acid) cycle in a cell. Prove reasoning to support your claims based on the position of the PDC- catalyzed reaction in the sequence of the cellular respiration pathway.