When an enzyme doesn't work properly it is said to be . Three things that can cause this are , and

Explanation:

When enzyme does not work properly it is said to be inactive and this affect its efficiency.

Substrate concentration - Enzyme requires adequate substrate concentration to be effective, when the concentration is high the enzyme activity increases and when it is low it decreases.

Temperature - Enzymes are more active at specific temperature at very high temperature enzyme can be denatured leading to a loss of its activity. Hence, enzyme should be made to work at its optimum.

pH- Enzymes are active at specific pH, when the pH is altered enzymatic activity may be reduced or enzyme become inactive. Hence, pH of enzymes should be maitained.

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