Do you think populations stay in genetic equilibrium after the environment has changed significantly?

Do you think populations stay in genetic equilibrium after the environment has changed significantly? ... It is likely because after the population changes, it is sufficient for its environment and does not need to go through change.

Explanation:

an active site is a region that is present on an enzyme where the reactants or the substrate molecules we can say bind and experience a chemical reaction. the substrate is basically a reactant whose concentration is changing and that is converting into a product after binding at the active site of an enzyme

the main thing i would use is bricks because if there is a hurricane, there is a great possibility for the house to still stand. and i would also use plexiglass windows instead of regular windows because plexiglass isn't prone to breaking.