4 A reaction that needs water,
macromolecules are broken down
( biochemistry )

Hydrolysis

Explanation:

Hydrolysis is a reaction that needs water to breakdown macromolecules into simpler units.

Macromolecules are giant polymers made up of several repeating monomeric units.

an active site is a region that is present on an enzyme where the reactants or the substrate molecules we can say bind and experience a chemical reaction. the substrate is basically a reactant whose concentration is changing and that is converting into a product after binding at the active site of an enzyme

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