A segment of DNA produces methionine, threonine, histidine, aspartate, and glycine when translated. A substitution mutation occurs and causes the synthesis of the segment as shown. New DNA Strand: 3' – TACAGGGTGCTACCCACT – 5' Which is the new peptide chain when the new DNA segment is translated?

AUGUCCCACGAUGGGUGA

Methionine- Serine- Histidine- Aspartate- Glycine- Stop

Explanation:

In gene expression, DNA, which is the genetic material is transcribed into mRNA, which is subsequently translated into a amino acid sequence (peptide). The transcription of DNA into mRNA follows complementary base pairing rule i.e. A-U, G-C, T-A.

The nucleotide sequence in the mRNA molecules are read in group of three nucleotide bases called CODONS. Each codon specifies an amino acid.

According to this question, a segment of DNA produces methionine, threonine, histidine, aspartate, and glycine when translated, however, a substitution mutation occurs and causes the synthesis of the segment as shown: 3' – TACAGGGTGCTACCCACT – 5'

The mRNA sequence from this mutated DNA sequence is as follows: AUGUCCCACGAUGGGUGA

During translation, the following codons specify the following amino acids:

AUG - methionine

UCC - Serine

CAC - Histidine

GAU - Aspartate

GGG - Glycine

UGA - Stop codon

Based on this, the new peptide chain when the new DNA segment is translated will be: Methionine- Serine- Histidine- Aspartate- Glycine- Stop

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