Trisomy 21 is a genetic disorder that occurs when a patient has three copies of chromosome 21 in each cell. Which mutation would most likely result in a similar phenotype as Trisomy 21?
A. Inversion of the distal portion of chromosome 21
B. Duplication of the distal portion of chromosome 21
C. Insertion of the distal portion of chromosome 21 to chromosome 5
D. Translocation of the distal portion of chromosome 21 two chromosome 5
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