Many genetic diseases result from the production of enzymes that are not shaped correctly. how does changing in an enzyme shape cause it to work poorly or not at all ?

The enzyme can't bind to the substrate.

hope it helps

primary succession begins with a bare rock and ends with a forest secondary succession begins after a natural disaster where there is a temporary setback after a forest fire or local destruction, but the surrounding area can fill in

"1. it should be, it has been for about 20 years, and it's really not much different in the end than breeding animals to have particular traits. there are always concerns about genetically engineered animals/plants affecting the environment in unexpected negative ways, but i can't think of an example where the fears didn't turn out to be baseless.  

first, as you point out, it would be a great advance in pharmacology, to be able to tailor drugs and their doses to me. the pros involve better medical treatment. the cons involve privacy issues like insurance companies denying coverage to people with genetic risk factors. looking at dna markers wouldn't affect the frequency of genetic diseases, but it would allow detection of them earlier. and ok, actually i suppose that if people used this information to avoid having children with genetic diseases, some might decrease in frequency."