Is knowing the ABO blood type of a potential blood donor enough to determine a suitable match? Explain your answer.

The most widely known blood group system is the ABO blood group system. The ABO system includes blood types A, B, and O. It is very important that a patient receives the most compatible blood products or life-threatening transfusion reactions may occur. Transfusion medicine departments in modern hospitals are responsible for matching blood to patients in need. Matching blood to a patient involves testing more than ABO blood groups.

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step 1: initiation

initiation is the beginning of transcription. it occurs when the enzyme rna polymerase binds to a region of a gene called the promoter. this signals the dna to unwind so the enzyme can ‘‘read’’ the bases in one of the dna strands. the enzyme is now ready to make a strand of mrna with a complementary sequence of bases.

step 2: elongation

elongation is the addition of nucleotides to the mrna strand. rna polymerase reads the unwound dna strand and builds the mrna molecule, using complementary base pairs. there is a brief time during this process when the newly formed rna is bound to the unwound dna. during this process, an adenine (a) in the dna binds to an uracil (u) in the rna.

step 3: termination

termination is the ending of transcription, and occurs when rna polymerase crosses a stop (termination) sequence in the gene. the mrna strand is complete, and it detaches from dna.