Researchers are investigating the effectiveness of various treatments on three individuals with a history of increased appetite. Individual I does not produce leptin but does have functional leptin receptors.
Individual II does produce leptin but does not have functional leptin receptors.
Individual III does not produce leptin and does not have functional leptin receptors.

Required:
Identify the way that leptin produced by fat cells of adipose tissue in the abdomen cansend a signal to the neuroendocrine cells in the hypothalamus.

Explanation:

The hypothalamus is the part of the brain that controls when and how much we eat.

Leptin is the hormone produced by fat cells in the adipose tissue, this implies the more fat you have the more Leptin you'll produce and vice versa.

However, the hormone Leptin is carried through the blood stream to the hypothalamus,where it sends signal to the brain.

tsd is temerature dependent sex determination.

tsd: it is a type of environmental sex determination in which the temperature experienced during embryonic/ larval development (ambient temperature for development) determine the sex of the offspring.

crocodile displays the tsd where the ambient temperature of the developing egg determines the individual's sex. for example in the american alligator's eggs, incubation at 33 ºc produces mostly males, while incubation at 30 ºc produces mostly females. so if the american alligator's egg will get the ambient temperature (33 degree celcius)during embryonic development from egg, the offspring will be male and same for the female sex determination.