Fill in the blanks by number Temperature and pH affect enzyme activity. As with all other reactions, enzyme-
catalyzed reactions __ 1_ in speed with an increase in temperature. However, as
the temperature increases beyond a critical point, the protein structure begins to get
disrupted resulting in ___2__ and loss of enzyme function. Every enzyme has a(n)
3___ temperature and activity tends to decrease on either side of this
temperature. Most human enzymes work best at around 4_Some enzymes
require nonprotein 5_such as zinc and manganese ions. Other enzymes may
require organic 6 such as vitamin C and vitamin D. A variety of substances
inhibit enzyme activity. ___7___ are so similar to the enzyme's substrate that they are
able to enter the enzyme's active site and block the normal substrate from binding.
This process is reversible and can be overcome by increasing the concentration of
the enzyme's substrate. Another class of inhibitors does not affect an enzyme at its
active site, they are called ___8__