Biology, 06.04.2021 01:10 allisonlillian

The activity of the pyruvate dehydrogenase complex is also controlled by phosphorylation. Pyruvate dehydrogenase kinase (PDH kinase) catalyzes the phosphorylation of a specific Ser residue on the E1 subunit of the enzyme, rendering it inactive. Pyruvate dehydrogenase phosphatase (PDH phosphatase) reverses the inhibition by catalyzing the removal of this phosphate group. The PDH kinase is highly regulated and its activity is influenced by various cellular metabolites. Indicate whether the following would activate or inhibit PDH kinase: Inhibit or activate PDK?
NAD+ activate
NADH inhibit
coenzyme A activate
acetyl-CoA inhibit
ADP inhibit
Did I answer these correctly?

Answers: 3

Show answers

Answers

Answer from: iBrain

Increase in [NAD+] inhibits Pyruvate dehydrogenase kinase (PDH kinase)

Increase in [NADH] activates Pyruvate dehydrogenase kinase (PDH kinase)

Coenzyme A inhibits Pyruvate dehydrogenase kinase (PDH kinase)

Acetyl-co A activates Pyruvate dehydrogenase kinase (PDH kinase)

ADP inhibits Pyruvate dehydrogenase kinase (PDH kinase)

Explanation:

Pyruvate dehydrogenase kinase, PDK is an enzyme which acts to inhibit the activity of the enzyme pyruvate dehydrogenase by phosphorylating it using ATP. It mechanism of action is by catalyzing the phosphorylation of a specific Ser residue on the E1 subunit of the pyruvate dehydrogenase complex, rendering it inactive. By inhibiting the activity of the pyruvate dehydrogenase complex, PDK will decrease the oxidation of pyruvate to acpcetyl-coA and CO₂ in the mitochondria and increase the conversion of pyruvate to lactate in the cytosol.

Since pyruvate dehydrogenase complex is activated by either an increase in the concentration of one or more of ADP, NAD+ or CoA-SH, its inhibitor pyruvate dehydrogenase kinase is inhibited by ADP, NAD+, CoA-SH and pyruvate. However, PDK is activated by increase in the concentration of ATP, NADH and acetyl-CoA.

Therefore, the correct answers are:

Increase in [NAD+] inhibits Pyruvate dehydrogenase kinase (PDH kinase)

Increase in [NADH] activates Pyruvate dehydrogenase kinase (PDH kinase)

Coenzyme A inhibits Pyruvate dehydrogenase kinase (PDH kinase)

Acetyl-co A activates Pyruvate dehydrogenase kinase (PDH kinase)

ADP inhibits Pyruvate dehydrogenase kinase (PDH kinase)

Answer from: Quest

The answer would be abrasion.

Answer from: Quest

Well, both latitude and intensity of light affect temperature because, the higher the light intensity, the higher the temperature and since latitude is the measure of how close you are to the equator, then the closer to the equator you are, the higher the temperature is.

Another question on Biology

Biology, 22.06.2019 03:30

Multicellular organisms use cell division, mitosis, for growth and the maintenance and repair of cells and tissues. single-celled organisms may use cell division as their method of reproduction. regardless of the reason for mitosis, the process ensures genetic continuity. what is the step in the cell cycle that ensure genetic continuity?

Answers: 3

Answer

Biology, 22.06.2019 05:40

Identify characteristics of energy from the sun. check all that apply. almost all of the energy on earth comes from the sun. energy from the sun is known as mechanical energy. the energy in fossil fuels originally came from the sun. plants convert the energy of sunlight into chemical energy.

Answers: 1

Answer

Biology, 22.06.2019 08:00

Choose the correct words to complete the sentences related to genetic screening. is a procedure that is used during pregnancy to detect genetic defects. is extracted from the uterus and used to identify genetic disorders?

Answers: 3

Answer

Biology, 22.06.2019 08:20

Which of these parts of the membrane large moecules pass through it ?

Answers: 1

Answer

You know the right answer?

The activity of the pyruvate dehydrogenase complex is also controlled by phosphorylation. Pyruvate d...

Questions

Biology, 25.06.2019 07:30

Can anyone me with this biology question? d: carbon dioxide and oxygen...